Govind Nair1, John D. Carew2,3,
1Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States; 2Institute for Health Studies, Carolinas HealthCare System, Charlotte, NC, United States; 3School of Public Health, Emory University, Atlanta, GA, United States; 4Department of Neurology, Emory University, Atlanta, GA, United States; 5Department of Epidemiology, Emory University, Atlanta, GA, United States
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease affecting the motor neurons in the brain and spinal cord. VBM analysis performed on T1-weighted images of the brain revealed significant changes in the motor cortex and supporting white matter of ALS patients compared with age-matched healthy control subjects. ROI analysis revealed a significant decrease in signal intensity from these regions, with signal intensity of ALS group showing significant correlation with clinical measures of disease severity. These findings suggest that T1-weighted images may have utility as an imaging biomarker of disease progression in ALS.