Irene Neuner1,2, Yuliya Kupriyanova3, Tony Stcker2,4, Oleg Posnansky2, Marc Tittgemeyer3, Frank Schneider1,4, N. J. Shah2,5
1Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany; 2Medical Imaging Physics, Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich, Juelich, Germany; 3Max-Planck-Institut fr Neurologische Forschung, Cologne, Germany; 4JARA Translational Brain Medicine, Germany; 5Department of Neurology,Faculty of Medicine, RWTH Aachen University, Aachen, Germany
White matter abnormalities in patients with Tourette syndrome are investigated using diffusion tensor imaging, Tract-Based Spatial Statistics and correlation analysis. Our results indicate that TS is not restricted to motor pathways alone but affects association fibres such as the inferior fronto-occipital fascicle, the superior longitudinal fascicle and fascicle uncinatus as well. The detected abnormalities in Tourette patients complement the idea of the developmental character of the disorder. They show a pathological pattern reaching beyond the corticospinal tract. The alteration pattern of decreased fractional anisotropy and increased radial diffusivity might indicate a deficit myelination as one pathophysiologic factor in Tourette.