Cathy Scanlon1, Susanne G. Mueller2,
Duygu Tosun2, Ian Cheong2, Michael W. Weiner2,
Ken D. Laxer3
1Center for Imaging of
Neurodegenerative Diseases , Dept. of Radiology and Biomedical Imaging,
University of California,, San Francisco, CA, United States; 2Center
for Imaging of Neurodegenerative Diseases, Dept. of Radiology and Biomedical
Imaging, University of California,, San Francisco, CA, United States; 3Pacific
Epilepsy Program, California Pacific Medical Center, San Francisco, CA,
United States
Deformation-based
morphometry (DBM) was applied to 2 sub-groups of temporal lobe epilepsy
(TLE); 15 patients with mesial temporal sclerosis (TLE-mts) and 14 with
normal MRI on visual inspection (TLE-no). TLE-mts demonstrated extensive
extra-hippocampal abnormalities when compared with controls (n=33). TLE-no
demonstrated more subtle but significant findings not previously reported
with a similar analysis in voxel based morphometry (VBM). This may suggest
DBM to be a more sensitive approach to detect subtle volume changes in this
group.