Santosh Kumar Yadav1, Amit Goel2,
Vivek A. Saraswat3, Arti Srivastava1, Sanjay Verma4,
Ram Kishore S. Rathore5, Michael A. Thomas6, Chandra M.
Pandey7, Kashi N. Prasad4, Rakesh K. Gupta1
1Radiodiagnosis, Sanjay Gandhi Post
Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Gastroenterology,
Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India,
Lucknow, UP, India; 3Gastroenterology, Sanjay Gandhi Post Graduate
Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 4Mathematics
and Statistics, Indian Institute of technology, Kanpur, UP, India; 5Mathematics
and Statistics, Indian Institute of technology Kanpur, Kanpur, Uttar Pradesh,
India; 6Radiological Sciences, UCLA School of Medicine, Los
Angeles, CA, Los Angeles, CA, United States; 7Biostatistics, Sanjay
Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India
Thirty-one
EHPVO patients along with 23 controls were included in this study. All
subjects underwent for neuropsychological tests, measurement of blood
ammonia, MR imaging, 1H-MR spectroscopy. Serum cytokines were measured only
in 10 patients and 8 controls. MHE was present in 45% patients. Significantly
increased ammonia, Glx/Cr, and cytokines and MD with decrease in mI/Cr and
MTR with no change in Cho/Cr were noted in patients with MHE compared to
controls. Significantly increased Glx/Cr and blood ammonia indicates its
central role in the pathogenesis of EHPVO related MHE. The presence of
significant increased serum cytokines in these patients suggest that
inflammation also pay an important role in the pathogenesis of MHE.