Daniel Joshua Cox1,2, Rafat S. Mohtasib3, Daniela Montaldi4, Laura M. Parkes1,2
1Imaging Sciences and Biomedical Engineering, School of Cancer and Imaging Sciences, The University of Manchester, Manchester, Lancashire, United Kingdom; 2Biomedical Imaging Institute (BII), The University of Manchester, Manchester, Lancashire, United Kingdom; 3Magnetic Resonance and Image Analysis Research Centre (MARIARC), University of Liverpool, United Kingdom; 4School of Psychological Sciences, The University of Manchester, Manchester, Lancashire, United Kingdom
This study aims to investigate changes in resting state functional connectivity with increasing age. 40 healthy subjects (aged 20 76) participated. Gradient echo EPI images were collected during a Stroop task and active regions were found across the group. The BOLD amplitude in the right middle frontal gyrus (MFG) increased with age, reducing laterality of activation. Partial correlation was used to investigate functional connectivity between bilateral MFG, which was found to increase with age between bilateral MFG in adults aged 40yrs+. Increased connectivity was also associated with improved accuracy, suggesting alterations in functional connectivity may be important for performance.