Kathrine T. Bluestein1, Cherian Renil
Zachariah1, Steffen Sammet1, Devin Elizabeth Prior1,
David Pitt2, Aaron Boster2, Amir Abduljalil1,
Michael V. Knopp1,
1Department of Radiology, The Ohio State University, Columbus, OH, United States; 2Department of Neurology, The Ohio State University, Columbus, OH, United States
Assessment of cortical lesions in MS is of significant interest, because correlation of conventional MRI with clinical findings is limited. However, detection of cortical lesions has been hampered by their small size and low contrast. In this study, we assessed cortical lesion detection in 7 MS patients and healthy controls at 7T using high resolution 3D T2* weighted, white matter attenuated (WHAT) turbo field echo and T1-weighted IR-TFE imaging. Cortical lesions were best seen with the WHAT sequence, and there was little reader variability.