Alexandra Marion Seewann1,2, Hugo Vrenken3,4,
Evert-Jan Kooi5, Paul van der Valk5, Dirk Knol6,
Chris Polman1, Petra Pouwels4, Frederik Barkhof3,
Jeroen Geurts, 3,5
1Neurology, VU University medical center,
Amsterdam, Netherlands; 2Neurology, Medical University Graz, Graz,
Austria; 3Radiology, VU University medical center, Amsterdam,
Netherlands; 4Physics and Medical Technology, VU University
medical center, Amsterdam, Netherlands; 5Pathology, VU University
medical center, Amsterdam, Netherlands; 6Epidemiology and
Biostatistics, VU University medical center, Amsterdam, Netherlands
Only
few lesions in cortical gray matter (CGM) of multiple sclerosis (MS) patients
can be visualized with conventional MRI. Quantitative MRI techniques are more
sensitive to cortical damage, but the histopathological correlates of
quantitative MRI changes in the MS CGM are unclear. We aimed to define the
underlying pathology of cortical quantitative MRI changes, and to compare MRI
visible and invisible lesions by histopathology. 16 brain slices from 10
chronic MS patients were imaged with qualitative and quantitative MRI at
1.5T. Regions of interests were correlated with histopathology.