Tobias Kober1,2, Cristina Granziera3,4, Delphine Ribes1,2, Patrick Browaeys5, Myriam Schluep6, Katrin Wohlfarth7, Reto Meuli5, Gunnar Krueger2
1Laboratory for functional and metabolic imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2Advanced Clinical Imaging Technology, Siemens Suisse SA - CIBM, Lausanne, Switzerland; 3Department of Neurology, Hpitaux Universitaires de Genve, Lausanne, Switzerland; 4Brain and Mind Institute, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 5Department of Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 6Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 7H IM MR PLM AW Neurology, Siemens AG, Erlangen, Germany
Detection and radiological characterisation of multiple sclerosis (MS) lesions is an essential part both of clinical diagnosis and MS research. Ten early-stage MS patients and ten controls were included in this study aiming at (i) comparing five different high-resolution imaging sequences (FLAIR, MP-RAGE, DIR, SPACE, MP2RAGE) and (ii) quantifying T1 relaxation times of lesions with respect to their location in the brain. Results suggest that the DIR sequence is the most sensitive for total lesion count, followed by the MP2RAGE. Confirming previous studies, T1 relaxation times were found to be overall prolonged.