Wolter L. de
Graaf1, J. M. Hoogduin2, F. Visser2,3, P.
Pouwels4, H. Vrenken4, C. H. Polman5, F.
Barkhof1, P. R. Luijten2, J. A. Castelijns1
1Radiology, VU University Medical Center,
Amsterdam, Netherlands; 2Image Science Institute, University
Medical Center Utrecht, Utrecht, Netherlands; 3PHILIPS Healthcare;
4Physics and Medical Technology, VU University Medical Center,
Amsterdam, Netherlands; 5Neurology, VU University Medical Center,
Amsterdam, Netherlands
In
Multiple Sclerosis, T1 mapping has shown to be able to differentiate normal
from normal appearing grey and white matter. At high field, T1 relaxation
times increase and therefore it is expected that changes in brain tissue due
to multiple sclerosis become more pronounced. A fast T1 mapping sequence of
4.5 minutes with an in-plane resolution of 1x1 mm2 and slice thickness of 1.5
mm is applied at 7 Tesla to assess the sensitivity of the method at high
field. Patients as well as healthy controls are examined and whole brain
histograms and analysis of specific brain regions are made.