Katherine A. Koenig1, Blessy Mathew1, Jian Lin1, Lael Stone2, Stephen Rao3, Michael Phillips1, Mark J. Lowe1
1Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States; 2Mellen Center, The Cleveland Clinic, Cleveland, OH, United States; 3Schey Center, The Cleveland Clinic, Cleveland, OH, United States
Nineteen patients with MS performed a verbal incidental encoding task, followed by a word recognition task (WR). Stimuli from the WR task were split into encoded and non-encoded based on performance of each subject. The encoded stimuli of the five highest performers were used to create an average t-map to select regions of interest for a correlation analysis. Areas involved in semantic encoding, including the DLPFC and the inferior frontal gyrus, showed a significant positive correlation between the fit hemodynamic response amplitude during encoded stimuli on the WR task and a test of verbal memory.