Katherine A. Koenig1, Blessy Mathew1, Jian Lin1, Lael Stone2, Stephen Rao3, Michael Phillips1, Mark J. Lowe1
1Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States; 2Mellen Center, The Cleveland Clinic, Cleveland, OH, United States; 3Schey Center, The Cleveland Clinic, Cleveland, OH, United States
Eighteen patients with MS performed a verbal incidental encoding task, followed by a word recognition task. Performance on the WR task was used to split incidental encoding stimuli into encoded and non-encoded maps. The fit hemodynamic response amplitude during encoded and non-encoded stimuli on the encoding task was correlated with a test of verbal memory. Against expectation, the non-encoded words showed only positive correlations, while the encoded words showed only negative correlations with verbal memory performance. It is unclear if this result is due to disease processes in MS, or due to compensatory strategies.