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Abstract #2108

In Vivo Measurement of Glutathione (GSH) in the Human Brain with Secondary Progressive Multiple Sclerosis Using Selective Multiple Quantum Chemical Shift Imaging of GSH

In-Young Choi1,2, Sang-Pil Lee1,3, Sharon G. Lynch4

1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States; 2Department of Neurology, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States; 3Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States; 4Department of Neurology, University of Kansas Medical Center, Kansas City, KS, United States


Oxidative stress has been implicated in multiple sclerosis (MS), a chronic inflammatory disease with the presence of a neurodegenerative process particularly in progressive MS. However, the effects of oxidative stress in MS have not been well described in the living human brain. In this study, we measured the cerebral GSH levels in the patients with secondary progressive MS (SPMS) using doubly selective multiple quantum GSH CSI. The GSH levels were significantly lower in the SPMS patients compared with those in the age- and gender-matched healthy controls, indicating the presence of increased oxidative stress in the absence of measurable inflammation.