Ileana Ozana Jelescu1, Ilana Ruth Leppert1, Sridar Narayanan1, Douglas L. Arnold1, G Bruce Pike1
1Montreal Neurological Institute,
Accurate and reproducible measurements of blood-brain barrier permeability in MS enhancing lesions would benefit follow-ups of lesion activity and comparison of detection sensitivity between different Gd-enhanced protocols. We propose a Dynamic Contrast Enhanced MRI protocol that allows sampling of the arterial input function with high temporal resolution in the first minute post-injection, followed by a lower temporal resolution but high spatial resolution acquisition of enhancement in lesions. This dual temporal resolution method was tested experimentally and through simulations and, compared to previous methods, has proven to yield more accurate and precise estimates over a wide range of permeability values.