Otto Rapalino1, Mara Kunst1, Patricia Musolino2, Florian Eichler2,3
1Radiology, Massachusetts General Hospital, Boston, MA, United States; 2Neurology, Massachusetts General Hospital, Boston, MA, United States; 3Martinos Center for Biomedical Imaging, Charlestown, MA, United States
Dynamic Susceptibility Contrast (DSC) MR perfusion was used to characterize the perfusion abnormalities in patients with adrenoleukodystrophy and adrenomyeloneuropathy. This study demonstrates that the combination of conventional MR and DSC perfusion MR techniques allows the definition of five different zones with characteristic profiles of abnormal signal and perfusion in patients with adrenoleukodystrophy that correspond to the zonal anatomy previously described on pathological studies. These findings can be helpful in predicting disease progression, selecting patients for therapeutic interventions and elucidating the pathophysiology of this disorder.