Viscoelastic Properties Change at an Early Stage of Cuprizone Induced Affection of Oligodendrocytes in the Corpus Callosum of C57/black6 Mice

Katharina Schregel¹, Eva Wuerfel¹, Jens Wuerfel¹, Dirk Petersen¹, Ralph Sinkus²

MRE is an innovative imaging technique developed to non-invasively map and quantify the viscoelastic properties of tissue in vivo. As pathological alterations cause changes in elasticity and viscosity, MRE might be applied to characterize the structural integrity of given tissues and could be employed for diagnosis and clinical monitoring of neurodegenerative diseases such as multiple sclerosis. Therefore it appears to be essential to evaluate the effect of pathological processes occurring in multiple sclerosis on the viscoelastic properties of cerebral tissue with the help of experimental rodent models. We introduced the cuprizone mouse-model (C57/black6) which depicts key features of multiple sclerosis.