Yu-Chun Lo1, Su-Chun Huang2, Hai-Gwo Hwu3, Chih-Min Liu3, Chen-Chung Liu3, Wen-Yih Isaac Tseng2,4
1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan; 2Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan; 3Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan; 4Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan
Three association fibers connecting the frontal and temporal lobes and three commissural fibers connecting the bilateral orbitofrontal lobes, inferior frontal gyri, and superior temporal gyri related to the social and language functions that might serve the neuropsychopathology of patients with schizophrenia inferred from diffusion spectrum imaging tractography. In neurotypical participants, a consistent leftward asymmetry in the three pairs of association fibers was found. However, adults with schizophrenia did not demonstrate such asymmetry. Lack of leftward asymmetry in schizophrenia may imply a disruption in the normal pattern of structural and functional connectivity in frontal-temporal brain regions.