Yu-Chun Lo1, Su-Chun Huang2,
Hai-Gwo Hwu3, Chih-Min Liu3, Chen-Chung Liu3,
Wen-Yih Isaac Tseng2,4
1Institute of Biomedical Engineering,
National Taiwan University, Taipei, Taiwan, Taiwan; 2Institute of
Biomedical Engineering, National
Taiwan University, Taipei, Taiwan, Taiwan; 3Department of
Psychiatry, National Taiwan University Hospital, Taipei, Taiwan; 4Center
for Optoelectronic Biomedicine, National Taiwan University College of
Medicine, Taipei, Taiwan
Three
association fibers connecting the frontal and temporal lobes and three
commissural fibers connecting the bilateral orbitofrontal lobes, inferior
frontal gyri, and superior temporal gyri related to the social and language
functions that might serve the neuropsychopathology of patients with
schizophrenia inferred from diffusion spectrum imaging tractography. In
neurotypical participants, a consistent leftward asymmetry in the three pairs
of association fibers was found. However, adults with schizophrenia did not
demonstrate such asymmetry. Lack of leftward asymmetry in schizophrenia may
imply a disruption in the normal pattern of structural and functional
connectivity in frontal-temporal brain regions.