Xin Hong1,2,
Lori R. Arlinghaus3, Herbert Y. Meltzer4, Sohee Park5,
Adam W. Anderson, 2,3
1Institute of Imaging Science,
Vanderbilt University , Nashville, TN, United States; 2Department
of Biomedical Engineering, Vanderbilt University, Nashville, TN, United
States; 3Institute of Imaging Science, Vanderbilt University,
Nashville, TN, United States; 4Department of Psychiatry,
Vanderbilt University, Nashville, TN, United States; 5Department
of Psychology, Vanderbilt University, Nashville, TN, United States
We
performed a group comparison of the diffusion properties and intravoxel fiber
coherence estimated by FORECAST analysis. Significantly higher FA is found in
schizophrenia patients compared to healthy controls in the left superior
longitudinal fasciculus and bilateral internal capsules. In all three
regions, strong negative correlation between FA and radial diffusivity is
found at both voxel and cluster levels, even after controlling for coherence
variation. Significantly lower coherence is found between the two groups at
the cluster level, but not voxel level. Our results suggest the altered FA
was mainly due to structural rather than organizational changes in these
regions.