Chun-Wei Lan1, Kun-Hsien Chou2, I-Yun Chen3, Ya-wei Cheng3, Jean Decety4, Yang-Teng Fan3, Ching-Po Lin1,3
1Institute of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan; 2Institute of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan; 3Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan; 4Departments of Psychology and Psychiatry, The University of Chicago, Chicago, United States
The autism spectrum disorders (ASD), during childhood, undergoes precocious growth, followed by maturation deceleration. But how the ASD brain changed during adolescence is unclear. We enrolled 25 male adolescents with ASD and 25 controls for voxel-based morphometric analysis. Global brain volume enlargement of ASD did not persist into adolescence. The right inferior parietal lobule and posterior cingulate cortex, a role in social cognition, had a significant interaction of age by group as indicated by an accelerated age-related loss in the adolescents with ASD but an age-related gain in the controls. The findings provided evidence of aberrant neurodevelopment in ASD.