Janneke Zinkstok1, Eileen Daly1,
Christine Ecker1, Patrick Johnston1,
1Section of Brain Maturation, Institute
of Psychiatry, London, United Kingdom; 2Centre of Neuroimaging
Sciences, Institute of Psychiatry, London, United Kingdom
Using
the novel Multi-Component Driven Equilibrium Single Pulsed Observation of T1
and T2 (mcDESPOT) method, we quantitatively compared myelin content between
individuals with autism and healthy controls.
We found significantly reduced myelin content in adults with autism in
brain regions previously implicated in autism, including the body of the
corpus callosum, and in frontal, temporal, parietal and occipital regions;
and in white matter tracts including the left and right uncinate, the left
inferior occipitofrontal tract, the left inferior cerebellar peduncle, the
left arcuate, the right anterior segment, the left inferior and superior
longitudinal fasciculus, and the posterior segments bilaterally.