Mareen Hoerst1,2, Wofgang Weber-Fahr1, Nuran Tunc-Skarka1, Matthias Ruf1, Martin Bohus2, Christian Schmahl2, Gabriele Ende1
1Department of Neuroimaging, Central
Institute of Mental Health,
Dysfunction and deficits in the structure of the anterior cingulate cortex (ACC) have been reported in borderline personality disorder (BPD). Impulsivity belongs to the key features of BPD and can be related to ACC function. In this study we found significantly increased self-reported impulsivity and higher levels of glutamate in the anterior cingulate cortex in subjects with BPD as compared to healthy controls. In both groups the ACC glutamate concentrations were positively correlated with self-reported impulsivity.