Yue Cao1, Felix Y. Feng, Diana Gomez-Hassan2, James A. Hayman, Theodore S. Lawrence, Christina I. Tsien
1Radiology and Radiation Oncology, University of Michigan, Ann Arbor, MI, United States; 2Radiology, University of Michigan, Ann Arbor, MI, United States
The response of metastatic lesions to whole brain radiation therapy (WBRT) is highly heterogeneous. In this study, we evaluated quantitative metrics derived from DCE MRI for early assessment of response of brain metastatic lesions to WBRT. We found that changes in vascular volume and perfusion at the completion of WBRT differentiated responsive lesions from non-responsive ones. These DCE metrics have the potential for early prediction of treatment response in brain metastases. This requires further validation, but may provide a means for individualizing therapy in patients with brain metastases by selecting patients requiring treatment intensification with stereotactic RT.