Meritxell Garcia1, Monika Gloor2, Christoph Stippich1, Felix Jax1, Klaus Scheffler2, Oliver Bieri2
1Department of Neuroradiology,
The efficacy of quantitative MT (qMT) imaging for characterization of benign and malignant brain lesions is analyzed with balanced steady-state free precession. Eleven patients with 3 different lesions (4 glioblastoma multiforme, 4 meningeomas and 3 metastases) were investigated on a clinical 1.5T MR-scanner. MT-effects are described in terms of MTR, relaxation times (T1, T2), MT exchange rate (kf) and the macromolecular content (F). Marked divergences between contrast-enhancing regions, edema and normal-appearing brain were found within and between the different lesions, which might be attributed to differences in edema, cell infiltration and myelin properties. Thus, qMT-imaging might play a major role in adding information for diagnostic tumor characterization.