Anitha Priya Krishnan1, Delphine Davis2,3, Paul Okunieff3, Walter G. O'Dell, 1,3
1Biomedical Engineering, University of Rochester, Rochester, NY, United States; 2Imaging Sciences, University of Rochester, Rochester, NY, United States; 3Radiation Oncology, University of Rochester, Rochester, NY, United States
The current methods for determining the treatment margin for Stereotactic Radiotherapy of gliomas are inadequate as recurrences often occur at the boundary of the treatment margin. We developed a random walk model to determine the microscopic spread of tumor cells to facilitate in the development of anisotropic treatment margins. In this study we have shown that the affinity of cancer cells to fibers in the brain can be modeled better by the spread in the direction of migration about the Principal Diffusion Direction determined using DTI than by using a variable step-size in the random walk of cancer cells.