Ona Wu1, Lee H. Schwamm2, Priya Garg1, Muhammed A. Pervez2, Albert J. Yoo3, Aurauma Chutinet2, Robert Irie1, Byeongseo Yook1, William A. Copen3, Pamela W. Schaefer3, Aneesh B. Singhal2, Karen L. Furie2, Alma Gregory Sorensen1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 2Department of Neurology, Massachusetts General Hospital; 3Department of Radiology, Massachusetts General Hospital
Approximately 25% of ischemic stroke patients have unwitnessed strokes and therefore ineligible for on label thrombolytic therapy. We investigated whether multiparametric MRI can be used for identifying patients who have early stage strokes (<=4.5 h). Acute DWI, PWI and FLAIR images from acute stroke patients imaged within 12 h since last known to be well (N=175) were analyzed. In regions that were DWI abnormal, there were significant difference in relative T2WI and FLAIR between patients seen within 4.5 h and those seen later. Multivariate logistic regression showed that T2WI, ADC, and CBV were predictive of patients with early onsets.