Ona Wu1, Lee H. Schwamm2, Priya
Garg1, Muhammed A. Pervez2, Albert J. Yoo3,
Aurauma Chutinet2, Robert Irie1, Byeongseo Yook1,
William A. Copen3, Pamela W. Schaefer3, Aneesh B.
Singhal2, Karen L. Furie2, Alma Gregory Sorensen1
1Athinoula A. Martinos Center for
Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United
States; 2Department of Neurology, Massachusetts General Hospital; 3Department
of Radiology, Massachusetts General Hospital
Approximately
25% of ischemic stroke patients have unwitnessed strokes and therefore
ineligible for on label thrombolytic therapy. We investigated whether
multiparametric MRI can be used for identifying patients who have early stage
strokes (<=4.5 h). Acute DWI, PWI and FLAIR images from acute stroke
patients imaged within 12 h since last known to be well (N=175) were
analyzed. In regions that were DWI abnormal, there were significant
difference in relative T2WI and FLAIR between patients seen within 4.5 h and
those seen later. Multivariate logistic regression showed that T2WI, ADC, and
CBV were predictive of patients with early onsets.