Jiabao He1, Dinesh Tryambake1,
Michael J. Firbank2, John T. OBrien2,
1Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 2Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
CBF determines brain tissue metabolic supply and is compromised in chronic hypertension which alters autoregulatory function. Blood pressure (BP) lowering therapy has clear clinical benefit but may risk inducing hypoperfusion. Optimal target BP in older subjects with hypertension is unclear, although guidelines recommend target BP of <130/85 mmHg and <140/80 mmHg for patients with and without previous vascular events respectively. We used ASL to determine the effect of usual (<140/85 mmHg) and intensive (<130/80 mmHg) BP lowering on CBF in older hypertensive subjects and demonstrate that intensive BP lowering increases CBF compared to usual BP lowering therapy.