Abstract #2226
Varied
Vasomotor Responses Among Brain Territories in Unilateral ICA Stenosis
Patients Studied Using Breath-Hold BOLD MRI
Wan Chun Kuan1, Ting Yu Chang2,
Keh Shih Chuang1, Ho Fai Wong3, Tsong Hai Lee2,
Ho Ling Liu4,5
1Dept. of Biomedical Engineering and
Environmental Sciences, National Tsing Hua Univ., Hsinchu, Taiwan; 2Stroke
Center, Department of Neurology, Chang Gung Memorial Hospital; 3Department
of Neuroradiology, Chang Gung Memorial Hospital; 4Dept. of Medical
Imaging and Radiological Sciences, Chang Gung Univ.; 5Dept. of
Medical Imaging and Intervention, Chang Gung Memorial Hospital
Impaired
cerebral vasoreactivity could be one of the predictors for hyperperfusion
after carotid interventions for patients with internal carotid artery (ICA) stenosis. This
study aimed to evaluate the differences of hemodynamic responses among
blood-supply territories, induced by vasodilatation following a
breath-holding task, in patients with unilateral ICA stenosis using BOLD MRI. The temporal
correlation between bilateral vasomotor responses in the MCA territories was
utilized as an index. The results
showed significantly impaired responses of the lesion side as compared to the
normal side (p<0.05) for patients exhibited hyperperfusion after the
stenting (sensitivity = 100%, specificity = 92.3%).
