Andrew Bresnen1, Fang Du1, Qiang
Shen1, Geoffrey Clarke2, Timothy Q. Duong1
1Research Imaging Institute, University
of
In
vivo 31P chemical shift imaging allows direct measurements of the high energy
phosphates. 31P NMR has proven useful for investigating the bioenergetics in
normal brain. However, the low SNR, long scan time and low spatial resolution
of 31P NMR have prevented its widespread use, particularly in the study of
acute stroke. This study implemented and optimized 31P CSI on rat brain with
high spatio-temporal resolution at 11.7T. This approach, along with 1H
diffusion, perfusion and T2 MRI, was used to investigate changes of high
energy phosphates in stroke rats at 1, 3 and 24 hrs after onset.