Andrew Bresnen1, Fang Du1, Qiang Shen1, Geoffrey Clarke2, Timothy Q. Duong1
1Research Imaging Institute, University
In vivo 31P chemical shift imaging allows direct measurements of the high energy phosphates. 31P NMR has proven useful for investigating the bioenergetics in normal brain. However, the low SNR, long scan time and low spatial resolution of 31P NMR have prevented its widespread use, particularly in the study of acute stroke. This study implemented and optimized 31P CSI on rat brain with high spatio-temporal resolution at 11.7T. This approach, along with 1H diffusion, perfusion and T2 MRI, was used to investigate changes of high energy phosphates in stroke rats at 1, 3 and 24 hrs after onset.