Qiang Shen1,2, Fang Du1, Shiliang Huang1, Timothy Q. Duong1,2
1Research Imaging Institute, University
Regional hyperperfusion after stroke is a frequent, yet poorly understood, phenomenon. In this study, multimodal MRI (diffusion, perfusion, T2, T1, pH-weighted and dynamic contrast-enhanced imaging, and MRA) were acquired in a 30-min transient MCAO in rat. Significant hyperperfusion was observed 24hrs post-occlusion and peaked at 48hrs. Hyperperfusion areas were consistent with regions with T1 and T2 increases, and early-phase pH decrease, and late-phase permeability changes. MRA showed significant vasodilatation of distal small arteries. We conclude that hyperperfusion does not appear to salvage tissue. Multimodality MRI investigation helps to gain significant insights into the underlying physiological changes associated with hyperperfusion.