Elan J. Grossman1, Yulin Ge1, Matilde Inglese1, Ke Zhang1, Jing An2, Ding Xia1, Jian Xu3, Niels Oesingmann3, Kelly A. Mcgorty1, Joseph Reaume1, Robert I. Grossman1, Qun Chen1
1Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, United States; 2Siemens Medical Solutions, Beijing, China; 3Siemens Medical Solutions, Malvern, PA, United States
Conventional imaging fails to reveal evidence of damage in mild traumatic brain injury (MTBI) that accounts for its disabling impairments. The purpose of the current study is to examine if perfusion changes in thalamus and basal ganglia can be a possible indicator of pathology in acute MTBI. We have employed segmented True-FISP ASL, which we recently developed to measure perfusion in deep gray matter at high spatial resolution. Results indicate there are significant differences between patients and controls in thalamus and caudate. This suggests these regions may exhibit hypoperfusion in acute MTBI and could be biomarkers of persistent post-concussive syndrome.