Willem M. Otte1,2, Rick M. Dijkhuizen2, Cornelis J. Stam3, Kajo van der Marel2, Maurits P.A. van Meer1,2, Max A. Viergever2, Kees P.J. Braun1
1Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands; 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 3Department of Clinical Neurophysiology, VU University Medical Center, Amsterdam, Netherlands
There is increasing evidence that the topology of brain networks may be changed in epilepsy. In particular, a random topology has been suggested as an explanation for lower seizure thresholds. To test this hypothesis, we assessed focal epileptic and healthy networks over time using resting state functional MRI and weighted graph theoretical analysis in a rat model. Brain networks in focal epilepsy were globally affected, toward a more ordered network topology. Networks largely normalized at ten weeks after epilepsy induction. Graph analysis provides a promising method to explore dynamical network alterations in epilepsy.