1C-TRIC and Radiology, University of Colorado Denver, Aurora, CO, United States; 2Neurology, University of Colorado Denver, Aurora, CO, United States; 3Institute of Cognitive Science, University of Colorado at Boulder, Boulder, CO, United States; 4Biostatistics and Psychology, UCLA, Los Angeles, CA, United States
Functional MRI (fMRI) is an important imaging modality to reveal altered function in neurodegenerative diseases. We hypothesize that functional changes in activation occur earlier and can be measured before structural degeneration is obvious. FMRI can potentially lead to an imaging marker for the early diagnosis of mild cognitive impairment (MCI) and furthermore may predict the development of Alzheimers disease (AD). In this work, we present fMRI results of 8 MCI and 8 normal subjects using different memory paradigms.