Natalia Petridou1, Ben M. Harvey2, Serge O. Dumoulin2, S F.W. Neggers3, Tjerk Gutteling3, Peter Luijten1, Hans Hoogduin1
1UMC Utrecht, Utrecht, Netherlands; 2Psychology, Utrecht University, Utrecht, Netherlands; 3Rudolf Magnus Institute for Neuroscience, UMC Utrecht, Utrecht, Netherlands
The advent of high fields has made it possible to reconstruct the functional organization of ocular-dominance columns in the human cortex with sub-millimeter in-plane (2D) resolution. However, 2D-based imaging techniques necessarily use anisotropic spatial resolution and are restricted to subjects that have relatively flat regions of cortex. Using 3D EPI with sub-millimeter isotropic resolution at 7T and a differential ocular stimulation we found alternating activation patterns in V1 which may relate to the expected ocular-dominance column distribution. This suggests that at 7T, 3D EPI can offer an avenue for sub-millimeter isotropic mapping not limited by the underlying anatomy.