Thomas R. Henry1, Marie Chupin2, Stphane Lehricy3, Kamil Ugurbil4, Frederick Ott5, Zhiyi Sha1, Pierre-Francois Van de Moortele5
1Neurology, University of Minnesota, Minneapolis, MN, United States; 2Universite Pierre et Marie Curie-Paris, Paris, France; 3Neuroradiology, Universite Pierre et Marie Curie-Paris, Paris, France; 4Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 5Radiology, University of Minnesota, Minneapolis, MN, United States
Increased contrast and spatial resolution at 7 T permitted the reliable detection of internal architecture of the hippocampal formation. Submillimetric T2w images at 7 T consistently resolved the continuous white matter band, which separates deep portions of CA1-3 from CA4 and the dentate hilus. The resulting accuracy permitted intrahippocampal (subregional) volumetry. These preliminary results strongly support expectations that brain imaging at very high magnetic field may allow for a more accurate patient classification based on qualitative and quantitative information that is difficult or impossible to collect reliably at lower field.