Eric Raymond Muir1,2, Timothy Q. Duong2
1Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States; 2Research Imaging Institute, Ophthalmology/Radiology, UT Health Science Center San Antonio, San Antonio, TX, United States
The retina can be divided into seven cellular and synaptic layers. It has been shown that intraocular injection of manganese enhances contrast in the rat retina, revealing 7 layers with MRI. Gadolinium-DTPA is a T1 shortening contrast agent like manganese, but the localization of the two within in a tissue could be expected to be to differ, potentially leading to different layer-specific enhancement. In this study we used intraocular injection of gadolinium to provide unique layer enhancement in the rat retina. Gadolinium-enhanced MRI clearly resolved six retinal layers at 25x25 m.