Wen-Tung Wang1, In-Young Choi1,2, Jieun Kim1, Sang-Pil Lee1
1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States; 2Neurology, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States
Magnetic resonance imaging is the only modality that can provide sufficient spatial resolution and image contrast to visualize Alzheimers amyloid plaques noninvasively. Previously Alzheimers amyloid plaques have been visualized in images acquired using spin-echo and gradient echo sequences at 7 T and 9.4 T. At high fields, it has been reported that the increased susceptibility-related contrast resulted in additional anatomical information, such as delineation of veins and iron-rich regions in human brain. In this study, we show that the susceptibility-induced contrast in gradient-echo phase images can improve detection of amyloid plaques.