Gopal Varma1, Prakash Saha2, Matt Waltham2, Stephen Keevil1,3, Alberto Smith2, Tobias Schaeffter1
1Imaging Sciences, King's College London, London, United Kingdom; 2Academic Department of Surgery, King's College London, London, United Kingdom; 3Medical Physics, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Subdural haematoma (SDH) is an emergency when acute, and management is often guided by imaging. Distinguishing between the different phases of SDH may be possible by the presence and position of methaemoglobin. In this study, we create an in vitro system of SDH and examine the relationship between intra- and extracellular methaemoglobin at various concentrations, using R2, R2* and R2’ parameters. R2’ relaxation rate appears to be the most sensitive marker of methaemoglobin concentration and can readily differentiate between when it is intra- or extracellular. This parameter could therefore be used to stage the phase of SDH.