Steven R. Roys1,2, Anjaneyulu Murugundla3, Su Xu1, Aurora Anderson3, Jiachen Zhuo1, Mark Limsam3, J Choi3, Lauren Koch4, Steve Britton4, Krish Chandrasekaran3, Paul Yarowsky5, James Russell3, Rao P. Gullapalli1,2
1Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States; 2Core for Translational Research in Imaging @ Maryland (C-TRIM); 3Neurology, University of Maryland School of Medicine, Baltimore, MD, United States; 4Anesthesiology, University of Michigan, Ann Arbor, MI; 5Experimental Therapeutics and Pharmacology, University of Maryland School of Medicine, Baltimore, MD, United States
Very little is understood regarding CNS changes that lead to various cognitive impairments among people with impaired glucose tolerance. Even less is understood regarding the differences between high performing diabetic patients versus the low performing diabetics. The purpose of this study was to examine the neurochemical profile differences between low capacity runner rats (LCR) and high capacity runner rats (HCR) using proton magnetic resonance spectroscopy at 7.0 Tesla. Findings suggest that LCR rats have elevated taurine, myo-inositol, glutamate and choline containing compounds compared to HCR rats consistent with similar findings in diabetic patients.