An in vitro proton MRS study was carried out on mice ranging from 3 to 18 months in order to investigate cerebral metabolic differences between TASTPM Alzheimer's mice and their wild type base strain. An effect of genotype was observed for myo-inositol, with concentration being higher in TASTPM mice, myo-inositol may therefore be an Alzheimer's marker. Lower levels of succinate were observed in TASTPM mice, being an effect of both age and genotype. This may indicate impaired neuronal energy production or mitochondrial dysfunction. The results also call into question the use of creatine as a reference metabolite.