Michael D. Boska1, Erin McIntyre1, Melissa Lynn Mellon1, Howard E. Gendelman2
1Radiology, University of Nebraska Medical Center, Omaha, NE, United States; 2Pharmacology and Experimental Neurosciences, University of Nebraska Medical Center, Omaha, NE, United States
Mouse brain structural and metabolic stability were determined by T1 and T2 mapping and DTI at 0.7 and 0.9 s of 4 kW FBMI and by quantitative single voxel PRESS, respectively. Measures were taken in-vivo before and repetitively, at 1.17 hour intervals, after FBMI. Analysis continued for a total duration of 16 hours at room temperature. The longer FBMI duration was best for maintaining metabolite levels in the mouse brain; whereas T1, T2, and DTI metrics were best maintained by shorter duration FBMI.