Sang-Young Kim1,2, Chi-Bong Choi3, Hyun-Sung Lee4, Sung-Ho Lee5, Dong-Cheol Woo1,2, Bo-Young Choe1,2
1Department of Biomedical Engineering, The Catholic University of Korea, Seoul, Korea, Republic of; 2Research Institute of Biomedical Engineering, Seoul, Korea, Republic of; 3Department of Radiology, Kyunghee University Medical Center, Seoul, Korea, Republic of; 4Korea Basic Science Institute, Korea, Republic of; 5Department of Veterinary Surgery, Konkuk University, Seoul, Korea, Republic of
Animal models for depression are indispensable tools in the search to identify new antidepressant drugs. The forced swimming test (FST) is the most widely used tool for assessing antidepressant activity in rodents. Few studies have been performed proton spectroscopy to assess antidepressant effects on brain metabolism of rat exposed to the FST. The in vivo proton spectra quantified by LCModel revealed that myo-inositol metabolic level in left dorsolateral prefrontal cortex of rat was significantly altered in both FST and desipramine treated group. Our findings suggest a possible role of myo-inositol within the left DLPFC of rat model for depression.