Sung-Tak Hong1, Dvid Zsolt Balla1,
Gunamony Shajan1, Changho Choi2, Rolf Pohmann1
1High-Field Magnetic Resonance Center ,
Max-Planck Institute for Biological Cybernetics, Tuebingen,
Baden-Wuerttemberg, Germany; 2Advanced Imaging Research Center,
University of Texas Southwestern Medical Center, Dallas, TX, United States
Regional
differences of metabolites in the rat brain were investigated by using
localized in vivo 1H MR spectroscopy at 16.4T. Three regions, thalamus,
striatum and hippocampus, were investigated with an ultra-short TE STEAM
sequence. The results demonstrated significant variations in all metabolites
except aspartate and NAA. The remarkable variation of spectra was the
substantially decreased level of the Tau methylene signal at 3.25 ppm in
thalamus. The significant increase of the GABA methylene signal at 1.89 ppm
was also observed in thalamus.