Giovanni Giulietti1,2, Federico Torelli1,3, Marco Bozzali1, Girolamo Garreffa1,2, Nicola Moscufo4, Silvana Zannino1,5, Laura Serra1, Fabio Placidi5, Fabrizio Fasano1, Gisela Hagberg1, Bruno Maraviglia1,2, Ina Djonlagic6, Julian Saboisky6, Atul Malhotra6, Maria Grazia Marciani1,5, Charles Guttmann4
1IRCCS "Santa Lucia Foundation", Rome, Italy; 2"Enrico Fermi" Center, Rome, Italy; 3Center for Neurological Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, United States; 4Center for Neurological Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, United States; 5Department of Neuroscience, University "Tor Vergata", Rome, Italy; 6Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States
This VBM study aims at investigating GM and WM changes which might account for clinical disabilities in patients with OSAS. Sixteen patients with OSAS (grouped in moderate and severe clinical stage) and 14 healthy controls were investigated. Neuropsychological assessment and MRI scanning were obtained from each subject. Patients reported a selective impairment of verbal memory. Subjects with severe OSAS showed a bilateral GM atrophy of the hippocampus and some volumetric reductions in the contiguous WM. These findings suggest that both regional GM atrophy and WM disconnection might, at least parially, explain cognitive deficits detectable in patients with OSAS.