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Abstract #2424

The Effects of HIV and Aging Using Diffusion Tensor Imaging

Huiling Peng1, Joseph Mettenburg2, Avi Snyder1, David Clifford1, Tammie Benzinger2, Beau Ances3

1Neurology, Washington University in St. Louis, St. Louis, MO, United States; 2Radiology, Washington University in St. Louis, St. Louis, MO, United States; 3Neurology, Washington University in St. Louis, St. Louis, MO , United States


HIV can lead to chronic inflammation. We investigated the relationship between aging and HIV status and white matter integrity using DTI in four groups of participants (HIV younger (20-25 years old) (n=8), HIV- older (50-65 years old) (n=12), HIV+ younger (20-25 years old) (n=9), and HIV+ older (50-65 years old) (n=9)). Regions-of-interest corresponding to the genus, middle, and splenium were selected. HIV- older subjects had significant decreases in mean diffusivity, axial diffusivity (AD), and radial diffusivity (RD) compared to other all groups. While HIV led to a reduction in DTI measures these decreases were not significant.