Darryl H. Hwang1, Sinchai Tsao1, Manbir Singh1
1Radiology and Biomedical Engineering,
The limbic regions appear to be affected by mild cognitive impairment (MCI) and Alzheimer Disease (AD). We use normalized tractography to objectively isolate the fornix and cingulum in a common template space for a voxel-based analysis of FA changes among normal control, MCI, and AD populations. The results show FA change propagation from normals to MCI to AD with more changes in the right hemisphere, which is consistent with previous reports.