Nasim Maleki1, Jaymin Upadhyay1, Jennifer Potter2, Roger Weiss, Lino Becerra1,3, David Borsook1
1PAIN Group, McLean Hospital, Harvard Medical School, Belmont, MA, United States; 2Division of Alcohol and Drug Abuse, Dept. of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, United States; 3Martinos Center, Massachusetts General Hospital, Charlestown, MA, United States
White matter abnormalities in a cohort of prescription opioid dependent subjects (vs. demographically matched subjects) are assessed by combining the parcellated structural and DTI data. Our results show that there are significant changes in white matter in the patient group in the form of reduced fractional anisotropy. The approach used in this study to evaluate white matter integrity has the major advantage of taking individual anatomical differences into account for DTI analysis.