Min Liu1, Donald Gross2, B.Matt Wheatley3, Christian Beaulieu1
1Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada; 2Neurology, University of Alberta, Edmonton, Alberta, Canada; 3Neurosurgery, University of Alberta, Edmonton, Alberta, Canada
Diffusion tensor imaging (DTI) may be a sensitive method of following the unique phases of Wallerian degeneration of injured white matter fibers in human brain. Longitudinal DTI tractography of the fimbria-fornix was performed at several time points on three patients with temporal lobe epilepsy before and after their anterior temporal resections (several times within the first week and 2-4 months post-surgery). The diffusion parameters of the ipsilateral fornices showed unique dynamic changes, notably a reduction of parallel diffusivity acutely, while perpendicular diffusion curiously showed a smaller reduction within the first week followed by the expected increase at chronic times.