John D. Carew1,2, Govind Nair3,
1Carolinas HealthCare System, Charlotte, NC, United States; 2Biostatistics and Bioinformatics, Emory University, Atlanta, GA; 3Biomedical Engineering, Emory University; 4Neurology, Emory University
We studied MRS in the cervical spinal cord of amyotrophic lateral sclerosis (ALS) patients, healthy controls, and people with a mutation in the SOD1 gene. Single voxel PRESS/CHESS MRS was used to measure NAA, choline, creatine, and myo-inositol. We found metabolic changes in both ALS and people positive for the SOD1 mutation. Among ALS patients, metabolite ratios correlate with clinical measures of disease severity. The findings in the SOD1 positive sample suggests that metabolic changes occur prior to the onset of clinical symptoms.