Jeon-Hor Chen1,2, Ke Nie1, S
Bahri1, Rita S. Mehta3, Chieh-Chih Hsu2,
Fei-Ting Hsu2, Han-Ni Shih2, Muqing Lin1,
orhang Nalcioglu1, M-Y Lydia Su1
1Center for Functional Onco-Imaging, UC
Irvine, Irvine, CA, United States; 2China Medical University
Hospital, Taichung, Taiwan; 3Department of Medicine, UC Irvine,
Irvine, CA, United States
We
have demonstrated the feasibility of investigating the reduction of density
following chemotherapy using a quantitative analysis method based on MRI.
Patients receiving chemotherapy showed reduction of breast density, and that
the effects were more pronounced in younger women than older
(post-menopausal) women. The results suggest that the reduction of breast
density after chemotherapy was possibly mediated through impaired ovarian
function. The reduction could be clearly noted after 1 to 2 cycles of AC
regimen. Although the density continued to decrease after 4 cycles of AC and
the following Taxane regimen, the subsequent effect was smaller.