Yogesh K. Mariappan1, Arunark Kolipaka1, Richard L. Ehman1, Kiaran P. McGee1
1Department of Radiology, Mayo Clinic,
Previous lung magnetic resonance elastography (MRE) animal experiments have indicated that it is feasible to quantitate the shear modulus of lungs with 1H MRI with the driver in direct contact with the lungs. Here, we tested the applicability of this technique in an in situ porcine model with a noninvasive mechanical driver placed on the chest wall. Further, the feasibility of this technique to measure the change in stiffness of the lung parenchyma as a function of transpulmonary pressure was also evaluated. It was found that lung stiffness can be quantified with this setup and that shear stiffness increases with increasing transpulmonary pressure.