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Abstract #2524

Blood Supply and Vascularization of Lung Cancer, Studies by MRI and Optical Imaging

Gregory Jacques Ramniceanu1, Erez Eyal2, Inbal Biton3, Nava Nevo2, Raanan Margalit4, Raya Eilam-Altstadter3, Hadassa Degani1

1Biological regulation, Weizmann Institute of Science, Rehovot, Israel; 2biological regulation, Weizmann Institute of Science, Rehovot, Israel; 3Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel; 4Immunology, Weizmann Institute of Science, Rehovot, Israel


The lung vasculature is composed of two systems, the bronchial and the pulmonary circulations. It is still unknown which of these two circulations, or both, contribute to the feeding of lung tumors during their progression .To answer this basic we characterize the perfusion parameters and the role of angiogenesis and interstitial fluid pressure in the lung tumors using MRI and optical imaging methods. Specifically we focus on imaging interstitial fluid pressure using a slow infusion protocol of the contrast agent.